HLA-G Monoclonal Antibody

Catalogue Numbers: MB66909-50, MB66909-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P17693

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: HLA-G is a non-classical MHC molecule expressed by trophoblasts in placenta, thymic epithelial cells, and some tumors.Alternative splicing leads to generation of at least six isoforms, four that are transmembrane proteins and two that are soluble. It is an inhibitory molecule involved in immune tolerance and escape, originally studied for its role in maternal tolerance of the fetus during pregnancy. HLA-G binds ILT2, ILT4, and KIR2DL4, playing a role in the regulation of natural killer, T, and monocyte/macrophage cells . Its involvement in evasion of immune response makes it a potential target for immunotherapy.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of HLA-G protein.

Extra Notes: Western blot analysis of HLA-G expression in A549 (A), Ramos (B), MDAMB231 (C) whole cell lysates.

Bioworld Molecular Weight: ~ 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: HLA-6.0; HLAG; HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; MHC class I antigen G

Immunogen: Recombinant fusion protein of human HLA-G. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified